The article discusses some key issues related to worldview in the work of Bruno Schulz, analyzing it through the lens of posthumanist philosophy. In the article, issues such as Schulzian anthropology, the notion of principium individuationis, and the position of the author of “The Street of Crocodiles” in relation to civilizational change are presented in discourse with critical readings of Schulz’s writing. Aspects hardly noticed in previous interpretations are brought to the fore, such as, the laboratory featured in the stories, and the depiction of Egga van Haardt and the convalescent in the essay “A Skeptic’s Wanderings”. The demiurgic acts of the Father in Schulz’s stories are considered in light of artistic activities within mainstream bio art. The author explores Schulz’s characteristic prosthetic principle of creation, relating it to both the construction of bodies and a philosophy of Schulz’s language.